Michael Platten Selected Research

Tryptophan (L-Tryptophan)

1/2021	Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas.
1/2021	Tryptophan metabolism in brain tumors - IDO and beyond.
1/2021	Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production.
1/2021	Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.
10/2020	Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.
1/2020	The therapeutic potential of targeting tryptophan catabolism in cancer.
1/2020	Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ.
10/2019	Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology.
1/2019	Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
1/2018	Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation.

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Michael Platten Research Topics

Disease

96	Neoplasms (Cancer) 06/2022 - 12/2003
69	Glioma (Gliomas) 05/2022 - 09/2003
58	Glioblastoma (Glioblastoma Multiforme) 06/2022 - 12/2003
24	Multiple Sclerosis 12/2022 - 10/2003
11	Brain Neoplasms (Brain Tumor) 01/2022 - 02/2015
10	Astrocytoma (Pilocytic Astrocytoma) 05/2022 - 07/2012
10	Inflammation (Inflammations) 03/2022 - 10/2007
6	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 11/2005
6	Neuroinflammatory Diseases 10/2019 - 11/2005
6	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2017 - 11/2005
4	Disease Progression 08/2022 - 01/2016
4	Stroke (Strokes) 01/2022 - 01/2018
4	Infections 10/2020 - 07/2012
3	Ischemic Stroke 01/2022 - 01/2020
3	Atrophy 01/2021 - 03/2019
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 10/2003
3	Starvation 08/2016 - 10/2007
2	Oligodendroglioma 05/2022 - 01/2015
2	Meningioma (Meningiomas) 12/2021 - 01/2018
2	Experimental Melanoma 01/2021 - 01/2016
2	Hypoxia (Hypoxemia) 01/2021 - 01/2014
2	Hypersensitivity (Allergy) 01/2020 - 01/2014
2	Melanoma (Melanoma, Malignant) 10/2019 - 02/2015
2	Edema (Dropsy) 04/2019 - 04/2011
2	Testicular Neoplasms (Testicular Cancer) 01/2019 - 11/2018
2	Breast Neoplasms (Breast Cancer) 01/2017 - 01/2015
2	Paralysis (Palsy) 08/2010 - 11/2005

Drug/Important Bio-Agent (IBA)

27	Tryptophan (L-Tryptophan)FDA Link 01/2021 - 11/2005
25	Biomarkers (Surrogate Marker)IBA 12/2021 - 11/2011
22	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 05/2022 - 09/2010
18	Temozolomide (Temodar)FDA LinkGeneric 11/2020 - 08/2007
16	EnzymesIBA 01/2021 - 10/2007
12	KynurenineIBA 01/2021 - 10/2007
11	AntigensIBA 05/2022 - 02/2015
11	Bevacizumab (Avastin)FDA Link 11/2020 - 03/2011
10	Proteins (Proteins, Gene)FDA Link 05/2022 - 12/2003
10	VaccinesIBA 01/2021 - 08/2014
8	Essential Amino AcidsIBA 01/2021 - 09/2012
8	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 11/2005
7	IronIBA 12/2022 - 01/2017
7	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2021 - 10/2011
7	MethyltransferasesIBA 01/2019 - 08/2007
6	Peptides (Polypeptides)IBA 05/2022 - 01/2016
6	Alkylating AgentsIBA 10/2014 - 02/2009
5	Pharmaceutical PreparationsIBA 06/2022 - 09/2009
5	Immune Checkpoint InhibitorsIBA 05/2022 - 01/2017
5	Biological ProductsIBA 11/2021 - 09/2011
5	Messenger RNA (mRNA)IBA 01/2018 - 09/2010
5	Phosphotransferases (Kinase)IBA 01/2018 - 11/2004
4	Neoplasm Antigens (Tumor Antigens)IBA 05/2022 - 11/2018
4	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022 - 01/2019
4	O(6)-Methylguanine-DNA MethyltransferaseIBA 07/2014 - 08/2013
4	LigandsIBA 04/2014 - 12/2003
3	Protein Subunit VaccinesIBA 05/2022 - 01/2021
3	GadoliniumIBA 12/2021 - 01/2019
3	Contrast MediaIBA 12/2021 - 03/2018
3	SodiumIBA 04/2021 - 04/2019
3	Cancer VaccinesIBA 01/2021 - 02/2015
3	Amino Acids FDA Link 01/2021 - 01/2017
3	Telomerase (Telomerase Reverse Transcriptase)IBA 11/2020 - 12/2013
3	Lomustine (CCNU)FDA Link 11/2019 - 01/2015
3	Transforming Growth Factors (Transforming Growth Factor)IBA 06/2017 - 11/2004
3	AntibodiesIBA 12/2016 - 08/2014
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2016 - 03/2011
3	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2015 - 10/2007
2	OvalbuminIBA 05/2022 - 01/2021
2	B7-H1 AntigenIBA 05/2022 - 01/2018
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2022 - 01/2019
2	Indicators and Reagents (Reagents)IBA 01/2021 - 06/2017
2	Codon (Codons)IBA 01/2021 - 01/2017
2	Hemoglobins (Hemoglobin)IBA 01/2021 - 03/2018
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 11/2020 - 01/2020
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 01/2015
2	DioxygenasesIBA 01/2020 - 09/2012
2	alpha-hydroxyglutarateIBA 11/2019 - 01/2017
2	ProteomeIBA 01/2019 - 11/2018
2	Fas Ligand Protein (Fas Ligand)IBA 01/2018 - 12/2014
2	APG101IBA 01/2018 - 12/2014
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2018 - 12/2013
2	EpitopesIBA 01/2017 - 02/2015
2	temsirolimus FDA Link 10/2016 - 03/2016
2	enzastaurinIBA 03/2016 - 10/2013
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 03/2016 - 10/2015
2	Retinaldehyde (Retinal)IBA 03/2016 - 01/2016
2	AutoantigensIBA 01/2016 - 11/2005
2	Small Interfering RNA (siRNA)IBA 01/2015 - 09/2011
2	O-(6)-methylguanineIBA 01/2015 - 08/2007
2	GlucocorticoidsIBA 01/2015 - 01/2014
2	Protein Kinases (Protein Kinase)IBA 01/2014 - 09/2013
2	Histones (Histone)IBA 08/2013 - 01/2012
2	Transforming Growth Factor beta (TGF-beta)IBA 08/2010 - 11/2004
2	CytokinesIBA 11/2005 - 11/2004
1	PhosphoproteinsIBA 01/2022

Therapy/Procedure

46	Therapeutics 12/2022 - 12/2003
31	Immunotherapy 05/2022 - 12/2003
18	Radiotherapy 01/2022 - 12/2008
17	Drug Therapy (Chemotherapy) 06/2022 - 08/2007
6	Chemoradiotherapy 11/2021 - 06/2013
2	Salvage Therapy 01/2019 - 03/2014
1	Kidney Transplantation 01/2022